Article: New Lyme's vaccine expected by 2026

[mazzgolf]

Article: https://archive.is/sD1VJ

(Archived from: https://www.bloomberg.com/news/features/2023-08-24/dogs-have-a-lyme-disease-vaccine-now-pfizer-is-making-one-for-people)

...

In 2002, three years after Lymerix’s introduction, it was shelved. ... The success of a vaccine is often as much about feelings as facts, and the feeling at the time was that one for Lyme was either unnecessary or unsafe.

But times change—at least, that’s what Pfizer Inc., in partnership with French drugmaker Valneva SE, is betting. Phase III trials are underway for their Lyme vaccine (dubbed VLA15 for now), which is expected to be available in 2026. So far scientists and executives at the companies suggest it’s likely to be safe and effective, since it works much the same way Lymerix did.

In the decades since Lymerix failed, Lyme has become the most common vector-borne (tick, mosquito, flea, etc., to human) illness in the US. The companies’ hunch is that its explosive growth will convince Americans that they need and want a Lyme shot. And for millions of people who’d like to avoid a potentially chronic illness, this will be welcome news.

...

Phase III trials are slated to wrap up in 2025, and Pfizer’s Anderson says they should show the new vaccine to be at least as effective as Lymerix. Recipients will likely need an annual booster after an initial series of three shots over the course of up to nine months.

Pfizer and Valneva aren’t alone. Moderna Inc. has a shot in development using the same mRNA technology behind its Covid vaccine, and a group at the UMass Chan Medical School in Boston announced it was working on a vaccine-like preventative shot that would require a new dose annually.

...

[jumpthestring]

They came up with the Covid Vaccine in 6 months. 

[BothBarrels]

I sure look forward to it. I hope all the anti-vaccine rhetoric doesn't kill it.

 

25 minutes ago, jumpthestring said:

They came up with the Covid Vaccine in 6 months. 

We tax payers put the money up for it. Removed all the risk for the drug companies. 

[mazzgolf]

6 minutes ago, BothBarrels said:

Removed all the risk for the drug companies. 

Yup. Lymerix didn't fail because it wasn't effective. And after it failed, it took 20 years for the drug companies to see the reward finally being worth the risk.

Quote

Lymerix was also approved the same year that a British physician named Andrew Wakefield published an explosive (and, eventually, discredited) paper linking the common childhood vaccine for measles, mumps and rubella to growing diagnoses of autism. When his theories crossed the Atlantic, they joined forces in the US with another vaccine myth in circulation: that a harmless, mercury-based vaccine preservative was also causing autism in kids. This combination essentially ushered in the modern era of vaccine hesitancy. And with so much anti-vax sentiment bubbling, it didn’t take long for concerns about the new Lyme shot to emerge, too ... And there was yet another issue. A vaccine called RotaShield, which was designed to prevent kids from catching rotavirus, the most common cause of diarrhea in young children, was withdrawn from the market after investigations revealed it significantly increased chances of a serious bowel obstruction in infants. “This was a one, two, three hit on vaccines,” says Paul Offit, director of the Vaccine Education Center at Children’s Hospital of Philadelphia and an adviser to the Food and Drug Administration. “Vaccines like Lyme suffered from all that.”

The maker of ImuLyme, a potential competitor, never even tried for FDA approval, presumably because of the hassle SKB faced and the lukewarm regulatory environment. 

 

[Batsto]

Let’s hope it’s a successful vaccine to fight Lyme.

[tpr1921]

I took the initial vaccine over 20 years ago and eagerly await the release of the new one. I have been following the reporting on the new vaccine and will be one of the first in line to get it if/when available. I have had Lymes 3 times to date, with the last time intravenous application needed. 

 

[LittleM]

10 hours ago, mazzgolf said:

suggest it’s likely to be safe and effective

 

10 hours ago, mazzgolf said:

The companies’ hunch is that its explosive growth will convince

All you need to know about modern day vaccines.

[JFC1]

1 hour ago, mazzgolf said:

Prudence, but not paranoia.

Well said

[electricstart]

I thought original vaccine worked, just like shot for poison Ivy vaccine but companies were not making money and took off market. Not cost effective. 

[Greybeard]

4 hours ago, tpr1921 said:

I took the initial vaccine over 20 years ago and eagerly await the release of the new one. I have been following the reporting on the new vaccine and will be one of the first in line to get it if/when available. I have had Lymes 3 times to date, with the last time intravenous application needed. 

 

Did you get lymes 3 times before you got vaccinated, and haven't had it in the last 20 years even though being bit by ticks that tested positive, and you had no reaction?  Or have you had lymes in the last 20 years since getting the shot?

[tpr1921]

53 minutes ago, Greybeard said:

Did you get lymes 3 times before you got vaccinated, and haven't had it in the last 20 years even though being bit by ticks that tested positive, and you had no reaction?  Or have you had lymes in the last 20 years since getting the shot?

The vaccine was a one-shot treatment with a booster promised years later but never came to be as it was taken off the market. It did not promise 100% efficacy, but I did not become infected the first time until well after 10 years of receiving it.

[mazzgolf]

21 hours ago, jumpthestring said:

21 hours ago, Greybeard said:

If they keep taking this stuff off the market because it doesn't make money than that pretty much says they are out to make money

That doesn't appear to be what doomed Lymerix. According to that article, it was pulled because of a confluence of things --  unwarranted/discredited anti-vax theories, a real problem with a vaccine but was unrelated to the Lyme's vaccine, and lawsuits which regulators said had no merit but still got settled out of court. Because of all that, less than 10,000 people voluntarily got the vax that last year before it was pulled. At that point, a person can't have it both ways. They can't say, "How can you trust any med from big pharma anymore? I'm never going to get it" and at the same time say, "Big pharma is pulling their meds only because they aren't making any money." Well, unless you are willing to work for free yourself or demand to live in a socialist society, you can't ask the workers in an industry to spend the time, money, and resources to produce a vaccine that people refuse to take (which apparently is what happened with Lymerix).

My wife recently had breast cancer (during 2020 covid year no less!) - and in the end, the chemo, radiation, and meds she took and is taking has made it almost like a "ho hum" disease - decades ago, it would have been a death sentence. Obviously, cancer isn't "ho hum" and she's one of the lucky ones, but thank God for our American pharma companies and the doctors/researchers that work with and for them. I hope those people get paid (they deserve more than the Kim Kardashians of the world). And I sure don't want the government to get into the big pharma business, because I know how government screws up mostly everything they touch.

Edited August 28, 2023 by Bucksnbows
Removing NMP content

[Jim_]

58 minutes ago, mazzgolf said:

.... My wife recently had breast cancer (during 2020 covid year no less!) - and in the end, the chemo, radiation, and meds she took and is taking has made it almost like a "ho hum" disease - decades ago, it would have been a death sentence. Obviously, cancer isn't "ho hum" and she's one of the lucky ones, but thank God for our American pharma companies and the doctors/researchers. ....

I remember you mentioned your wife here once back then. I felt that my asking you how she was, might be intruding on you guys. But, I was thinking about her.

So, terrific news! So glad for the good outcome!

Count me in on appreciating what pharma does for mankind. I hope mRNA technology lives up to its potential.

[LeakyBoots]

Just finished up a round of antibiotics for what was/is my third round of lyme's disease.  No idea how long I may have had it since I don't recall being bitten by a tick in a few years at least.  Anyway, I'll be glad to see a vaccine, though I won't be first in line.  A little "watch and wait" might be the way to approach it.

[FishNHard]

Isn't there a new tick found that's has now cure for it as of now.

Edited August 28, 2023 by FishNHard